This article is about the dimpled appearance of skin. For the infection of skin and its underlying connective tissue, see cellulitis. Not to be confused with Celluloid.

Cellulite
The dimpled appearance of cellulite
Classification and external resources

Cellulite (also known as adiposis edematosa, dermopanniculosis deformans, status protrusus cutis, gynoid lipodystrophy, and orange peel syndrome) is the herniation of subcutaneous fat within fibrous connective tissuethat manifests topographically as skin dimpling and nodularity, often on the pelvic region (specifically the buttocks),lower limbs, and abdomen.^[1][2] Cellulite occurs in most postpubescent females.^[3] A review gives a prevalence of 85%-98% of women,^[4] indicating that it is physiologic rather than pathologic. It can result from a complex combination of factors ranging from hormones to heredity.

Causes[edit]

The causes of cellulite^[5] include changes in metabolism, physiology, dieting too hard or too much, sex-specific dimorphic skin architecture, alteration of connective tissue structure, hormonal factors, genetic factors, the microcirculatory system, the extracellular matrix, and subtle inflammatory alterations.^[1][3][5][6]

Hormonal factors

Hormones play a dominant role in the formation of cellulite. Estrogen may be the important hormone to initiate and aggravate cellulite. However, there has been no reliable clinical evidence to support such a claim. Other hormones, including insulin, the catecholamines adrenaline and noradrenaline, thyroid hormones, andprolactin, are all believed to participate in the development of cellulite.^[1]

Genetic factors

There is a genetic element in individual susceptibility to cellulite.^[1] Researchers led by Enzo Emanuele have traced the genetic component of cellulite to particularpolymorphisms in the angiotensin converting enzyme (ACE) and hypoxia-inducible factor 1A (HIF1a) genes.^[7]

Predisposing factors

Several factors have been shown to affect the development of cellulite. Sex, race, biotype, distribution of subcutaneous fat, and predisposition to lymphatic and circulatory insufficiency have all been shown to contribute to cellulite.^[1]

Lifestyle

A high-stress lifestyle will cause an increase in the level of catecholamines, which have also been associated with the development of cellulite.^[1]

Treatments[edit]

Cellulite is a multifactorial condition^[8] that is unresponsive to a wide array of treatments. However there are currently many possible treatment of cellulite as skin care and non-invasive therapy (mainly radio frequency with deep penetration on the skin).^[9]

Epidemiology[edit]

Cellulite is thought to occur in 80–90% of post-adolescent females.^[7][10] There appears to be a hormonal component to its presentation. Its existence as a real disorder has been challenged,^[11] and the prevailing medical opinion is that it is merely the "normal condition of many women".^[12] It is rarely seen in males,^[1] but is more common in males with androgen-deficient states, such as Klinefelter's syndrome, hypogonadism, postcastration states and in those patients receiving estrogen therapy for prostate cancer. The cellulite becomes more severe as the androgen deficiency worsens in these males.^{[citation needed]}

History[edit]

The term was first used in the 1920s by spa and beauty services to promote their services, and began appearing in English language publications in the late 1960s, with the earliest reference in Vogue magazine, "Like a swift migrating fish, the word cellulite has suddenly crossed the Atlantic."^[13] Its existence as a real disorder has been challenged,^[11] and the prevailing medical opinion is that it is merely the "normal condition of many women".^[14]

External links[edit]

•  Media related to Cellulite at Wikimedia Commons